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Methylone: Distinct Pharmacological and Mechanistic Effects Compared with MDMA
Poster Presentation

Methylone: Distinct Pharmacological and Mechanistic Effects Compared with MDMA

Poster presented at American Society of Clinical Psychopharmacology (ASCP) in June 2023, and Society for Neuroscience in November 2023

Conclusions:

In clinical and preclinical studies, methylone and MDMA show potential efficacy for treating PTSD but with notable differences in their mechanisms of action and observed clinical effects.

• Both act on monoamine transporters, but with different relative potencies. Methylone also appears to have no off-target effects versus MDMA, which acts of 5HT2A, 5HT2B, 5HT2C receptors and others reported in the literature.

• Gene expression studies suggest that MDMA regulates more gene targets than methylone, likely due to activation of 5HT receptors (and others). Overlapping gene changes may reflect those relevant for therapeutic efficacy.

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